CHIMIA 11/2011, Vol. 65

NCCR Chemical Biology 2011 11

Scientific Content

All articles of this issue are available on Ingenta.

To access the articles you must be a SCS member or a CHIMIA subscriber.


The National Centre of Competence in Research (NCCR) «Chemical Biology – Visualisation and Control of Biological Processes Using Chemistry» uses chemistry tools to obtain a better understanding of life at the molecular level. Until now, a few technologies could characterise in detail the countless biochemical activities that constitute a living cell. In the NCCR Chemical Biology, chemists, biochemists, physicists and cell biologists develop innovative techniques based on small molecules and proteins to obtain new information about cellular processes and control them in situ. The new tools will be applicable to various biological phenomena like visualising the activity of selected proteins during cell division and investigating how membranes control the activity of proteins in them. The NCCR is also engaged in establishing a platform for chemical screening aimed at developing a new generation of molecules with biological effects.

Cover photo: This fluorescence micrograph simultaneously visualizes the structure of microtubules (in green) and protein–protein interactions of microtubule-associated proteins (red dots) in cells. The nucleus of the cell is shown in blue. Photo provided by Kai Johnsson, EPFL.


Additional content

Contents 830 Icon FreeContent
Editorial 832 Icon FreeContent
835 Icon OpenAccessContent
  839 Icon OpenAccessContent
  843 Icon OpenAccessContent
  846 Icon OpenAccessContent
  849 Icon OpenAccessContent
Icon ExternalLink

Chemical Biology Approaches to Membrane Homeostasis and Function
M. Takahashi-Umebayashi, L. Pineau, T. Hannich, A. Zumbuehl, D. A. Doval, S. Matile, C. Heinis, G. Turcatti, R. Loewith, A. Roux, L. Reymond, K. Johnsson, H. Riezman* 

  853 Icon OpenAccessContent
Icon ExternalLink

Conceptually New Entries into Cells
J. Montenegro, C. Gehin, E.-K. Bang, A. Fin, D. A. Doval, H. Riezman*, N. Sakai, S. Matile* 

  859 Icon OpenAccessContent

Icon ExternalLinkPutting the ‘P’ into Phospholipids
I. A. Fedotenko, M. N. Holme, R. Tanasescu, P.-L. Zaffalon, A. Zumbuehl* 

  863 Icon OpenAccessContent
  868 Icon OpenAccessContent

Icon ExternalLinkVisualizing Biochemical Activities in Living Cells through Chemistry
L. Reymond, G. Lukinavicˇ ius, K. Umezawa, D. Maurel, M. A. Brun, A. Masharina, K. Bojkowska, B. Mollwitz, A. Schena, R. Griss, K. Johnsson* 

  872 Icon OpenAccessContent
SCG/SSC/SCS     875  Icon FreeContent
877 Icon FreeContent
883 Icon FreeContent
884 Icon FreeContent
Information 885  Icon FreeContent
CHIMIA-Report 888 Icon FreeContent
Icon FreeContent Free Content
Icon OpenAccessContent Open Access Content
Icon SubscribedContent Subscribed Content. To access the articles you must be a SCS member or a CHIMIA subscriber.